Benznidazole vs benznidazole in multilamellar liposomes: how different they interact with blood components?
نویسندگان
چکیده
منابع مشابه
Benznidazole vs benznidazole in multilamellar liposomes: how different they interact with blood components?
In spite of its widespread use, benznidazole's (BNZ) toxicity and low efficacy remains as major drawbacks that impair successful treatments against Chagas disease. Previously, attempting to increase the selectivity and reduce its toxicity on infected tissues, multilamellar liposomes (MLV) composed of hydrogenated soybean phosphatidylcholine (HSPC): distearoyl-phosphatidylglycerol (DSPG): choles...
متن کاملBenznidazole
THE CONFORMATION OF THE TITLE COMPOUND [SYSTEMATIC NAME: N-benzyl-2-(2-nitro-imidazol-1-yl)acetamide], C(12)H(12)N(4)O(3), can be described in terms of the relative orientation of three planar fragments, the imidazol group (A), benzyl group (B), and the acetamide fragment (C), with corresponding dihedral angles: A/C = 88.17 (4), B/C = 67.12 (5) and A/B = 21.11 (4)°. The crystal packing is enhan...
متن کاملAdverse systemic reaction to benznidazole.
Benznidazole, drug of choice for Chagas disease (CD), has been associated with a high incidence of adverse reactions that can become serious, necessitating discontinuation of the drug. We describe the case of a Bolivian patient living in Spain for 9 years, who, following treatment with benznidazole for CD in indeterminate chronic phase, presented with fever, skin lesions, digestive symptoms, ge...
متن کاملBenznidazole for Chronic Chagas’ Cardiomyopathy
To the Editor: The Benznidazole Evaluation for Interrupting Trypanosomiasis (BENEFIT) trial, reported by Morillo et al. (Oct. 1 issue),1 showed that trypanocidal therapy with benznidazole in patients with Chagas’ cardiomyopathy significantly reduced polymerase-chain-reaction (PCR)– based parasite detection in serum samples but did not significantly reduce clinical deterioration of cardiac funct...
متن کاملBenznidazole Treatment of Chagasic Encephalitis in Pregnant Woman with AIDS
We report a case of chagasic meningoencephalitis reactivation in a pregnant woman co-infected with Trypanosoma cruzi and HIV that was successfully managed with benznidazole and highly active antiretroviral therapy. Early diagnosis enabled rapid specific treatment that improved the health of the patient and her baby.
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Memórias do Instituto Oswaldo Cruz
سال: 2005
ISSN: 0074-0276
DOI: 10.1590/s0074-02762005000200017